Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism

João M.N. Duarte, Lijing Xin

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in neuropsychiatric disorders, namely schizophrenia. Alterations of glutamate and glutamine levels in brains of schizophrenia patients relative to healthy subjects are generally interpreted as markers of glutamatergic dysfunction. However, only a small fraction of MRS-detectable glutamate is involved in neurotransmission. Here we review and discuss brain metabolic processes that involve glutamate and that are likely to be implicated in neuropsychiatric disorders.

Originalspråkengelska
Sidor (från-till)102-116
Antal sidor15
TidskriftNeurochemical Research
Volym44
Nummer1
Tidigt onlinedatum2018 apr. 3
DOI
StatusPublished - 2019

Ämnesklassifikation (UKÄ)

  • Radiologi och bildbehandling
  • Neurologi

Fingeravtryck

Utforska forskningsämnen för ”Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här