Mapping the architecture of the temporal artery with photoacoustic imaging for diagnosing giant cell arteritis

Magdalena Naumovska, Aboma Merdasa, Björn Hammar, John Albinsson, Ulf Dahlstrand, Magnus Cinthio, Rafi Sheikh, Malin Malmsjö

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Photoacoustic (PA) imaging is rapidly emerging as a promising clinical diagnostic tool. One of the main applications of PA imaging is to image vascular networks in humans. This relies on the signal obtained from oxygenated and deoxygenated hemoglobin, which limits imaging of the vessel wall itself. Giant cell arteritis (GCA) is a treatable, but potentially sight- and life-threatening disease, in which the artery wall is infiltrated by leukocytes. Early intervention can prevent complications making prompt diagnosis of importance. Temporal artery biopsy is the gold standard for diagnosing GCA. We present an approach to imaging the temporal artery using multispectral PA imaging. Employing minimally supervised spectral analysis, we produce histology-like images where the artery wall is clearly discernible from the lumen and further differentiate between PA spectra from biopsies diagnosed as GCA- and GCA+ in 77 patients.
Originalspråkengelska
Artikelnummer100384
TidskriftPhotoacoustics
Volym27
Tidigt onlinedatum2022 juli 4
DOI
StatusPublished - 2022 sep. 1

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi
  • Kirurgi

Nyckelord

  • Photoacoustic imaging
  • Giant cell arteritis
  • Unsupervised spectral analysis
  • Noninvasive, clinical diagnosis

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