Meandering nanochannels for imaging of ultra-long DNA molecules

C. Freitag, J. Fritzsche, F. Persson, Kalim U. Mir, J. O. Tegenfeldt

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceedingForskningPeer review

Sammanfattning

A new chip design for handling and studying chromosomal DNA is described. Folding the nanochannels enables us to image an entire yeast chromosome in a single field of view. Together with existing mapping techniques our new design opens up the possibility of directly analyzing entire chromosomes in a single field of view using fluorescence microscopy. This would enable, for example, identification of microorganisms on a single-cell basis and the complete physical mapping of the human genome, chromosome by chromosome.

Originalspråkengelska
Titel på gästpublikation15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Sidor1758-1760
Antal sidor3
Volym3
StatusPublished - 2011 dec 1
Evenemang15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, USA
Varaktighet: 2011 okt 22011 okt 6

Konferens

Konferens15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Land/TerritoriumUSA
OrtSeattle, WA
Period2011/10/022011/10/06

Ämnesklassifikation (UKÄ)

  • Medicinsk genetik
  • Cellbiologi

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