Metabolic and Lifestyle related risk factors for pancreatic cancer

Dorthe Johansen

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

146 Nedladdningar (Pure)

Sammanfattning

Background and aims: In spite of the fact that pancreatic cancer is a relatively infrequent disease, it ranks
8th in the worldwide ranking of cancer death due to the poor prognosis. The mortality rate is almost as
high as the incidence with a M/I ratio of 98%, indicating an extremely dismal clinical course. This makes
it imperative to try to develop new therapeutic strategies and to try to identify risk factors in order to intensify
preventive efforts. The most important risk factor for pancreatic cancer is tobacco smoking, but
there are other putative environmental risk factors and some pre-existing diseases that have been linked
to pancreatic cancer. The aim of this thesis is to evaluate different epidemiological aspects in relation to
pancreatic cancer; in more specific terms to investigate the relation between alcohol and pancreatic cancer,
between trypsinogen, pancreatic secretory trypsin inhibitor (PSTI) and pancreatic cancer, between Helicobacter
pylori infection and pancreatic cancer and to investigate if the metabolic syndrome is associated
with the risk of pancreatic cancer.
Results and conclusion: High alcohol intake, estimated using both a questionnaire on attitude towards
alcohol and a laboratory marker in the form of γ-GT is associated with a subsequent high risk of developing
pancreatic cancer. The previously established association between smoking and pancreatic cancer
is confirmed. The hypothesis that pancreatic cancer is related to an imbalance between the trypsinogen
isoforms is in line with the finding concerning the ratio of human anionic trypsinogen and human cationic
trypsinogen (HAT/HCT). There is no overall association between H.pylori infection and the risk of
pancreatic cancer, but H.pylori infection may increase the risk of pancreatic cancer in never smokers and
in low alcohol consumers. High mid-blood pressure, high fasting glucose and the metabolic syndrome as
an entity are associated with an increased risk of pancreatic cancer in women. In men, high mid-blood
pressure is associated with the risk of pancreatic cancer and there is an indication of an association between
high glucose levels and the risk of pancreatic cancer. Growing evidence have consistently shown that obesity,
diabetes, metabolic factors, smoking and alcohol are associated with a high risk of pancreatic cancer.
Originalspråkengelska
KvalifikationDoktor
Tilldelande institution
  • Institutionen för kliniska vetenskaper, Malmö
Handledare
  • Manjer, Jonas, handledare
  • Lindkvist, Björn, handledare
Tilldelningsdatum2010 apr. 16
Förlag
ISBN (tryckt)978-91-86443-44-3
StatusPublished - 2010

Bibliografisk information

Defence details

Date: 2010-04-16
Time: 13:15
Place: CRC, föreläsningssalen, Malmö

External reviewer(s)

Name: Bergkvist, Leif
Title: Prof.
Affiliation: Centrum för klinisk forskning, Kirurgiska kliniken, Centrallasarettet Västerås

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The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

Ämnesklassifikation (UKÄ)

  • Klinisk medicin

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