Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

Theeraphon Piacham; C Isarankura-Na-Ayuldhya; C Nantasenamat; S Yainoy; Lei Ye; Leif Bülow; V Prachayasittikul

doi:10.1016/j.bbrc.2006.01.045

Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

Theeraphon Piacham, C Isarankura-Na-Ayuldhya, C Nantasenamat, S Yainoy, Lei Ye, Leif Bülow, V Prachayasittikul

Tillämpad biokemi

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.

Originalspråk	engelska
Sidor (från-till)	925-930
Tidskrift	Biochemical and Biophysical Research Communications
Volym	341
Nummer	4
DOI	https://doi.org/10.1016/j.bbrc.2006.01.045
Status	Published - 2006

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10.1016/j.bbrc.2006.01.045

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@article{ef71350b48bd4d5a94f09843dfceccff,

title = "Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase",

abstract = "Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.",

keywords = "molecular, modeling, SOD mimic, SOD, superoxide dismutase, antibiotic, bacitracin",

author = "Theeraphon Piacham and C Isarankura-Na-Ayuldhya and C Nantasenamat and S Yainoy and Lei Ye and Leif B{\"u}low and V Prachayasittikul",

year = "2006",

doi = "10.1016/j.bbrc.2006.01.045",

language = "English",

volume = "341",

pages = "925--930",

journal = "Biochemical and Biophysical Research Communications",

issn = "1090-2104",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

AU - Piacham, Theeraphon

AU - Isarankura-Na-Ayuldhya, C

AU - Nantasenamat, C

AU - Yainoy, S

AU - Ye, Lei

AU - Bülow, Leif

AU - Prachayasittikul, V

PY - 2006

Y1 - 2006

N2 - Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.

AB - Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. (c) 2006 Elsevier Inc. All rights reserved.

KW - molecular

KW - modeling

KW - SOD mimic

KW - SOD

KW - superoxide dismutase

KW - antibiotic

KW - bacitracin

U2 - 10.1016/j.bbrc.2006.01.045

DO - 10.1016/j.bbrc.2006.01.045

M3 - Article

C2 - 16455051

SN - 1090-2104

VL - 341

SP - 925

EP - 930

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase

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