Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.

Sarah Piel; Johannes Ehinger; Eskil Elmer; Magnus Hansson

doi:10.1111/apha.12311

Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.

Sarah Piel, Johannes Ehinger, Eskil Elmer, Magnus Hansson

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.

Originalspråk	engelska
Sidor (från-till)	171-180
Tidskrift	Acta Physiologica
Volym	213
Nummer	1
DOI	https://doi.org/10.1111/apha.12311
Status	Published - 2015

Ämnesklassifikation (UKÄ)

Fysiologi

Tillgång till dokument

10.1111/apha.12311

http://www.ncbi.nlm.nih.gov/pubmed/24801139?dopt=Abstract

1 Artikel i vetenskaplig tidskrift
1 Doktorsavhandling (sammanläggning)

Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production
Piel, S., Ehinger, J. K., Chamkha, I., Frostner, E. Å., Sjövall, F., Elmér, E. & Hansson, M. J., 2018 aug. 1, I: Intensive Care Medicine Experimental. 6, 1, 22.
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Öppen tillgång
Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse.
Piel, S., 2018, Lund: Lund University: Faculty of Medicine. 77 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

Öppen tillgång
Fil

3 Deltagit i konferens
1 Presentation

Mitochondrial Medicine
Sarah Piel (deltagare)
2016 maj 4 → 2016 maj 6
Aktivitet: Deltagit i eller arrangerat evenemang › Deltagit i konferens
Summer school on Mitochondrial Physiology
Sarah Piel (Talare)
2015 aug. 18 → 2015 aug. 20
Aktivitet: Föredrag eller presentation › Presentation
The United Mitochondrial Disease Foundation Symposium 2014
Sarah Piel (deltagare)
2014 juni 4 → 2014 juni 7
Aktivitet: Deltagit i eller arrangerat evenemang › Deltagit i konferens

Citera det här

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title = "Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.",

abstract = "Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.",

author = "Sarah Piel and Johannes Ehinger and Eskil Elmer and Magnus Hansson",

year = "2015",

doi = "10.1111/apha.12311",

language = "English",

volume = "213",

pages = "171--180",

journal = "Acta Physiologica",

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TY - JOUR

T1 - Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.

AU - Piel, Sarah

AU - Ehinger, Johannes

AU - Elmer, Eskil

AU - Hansson, Magnus

PY - 2015

Y1 - 2015

N2 - Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.

AB - Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incidence of lactic acidosis.

U2 - 10.1111/apha.12311

DO - 10.1111/apha.12311

M3 - Article

C2 - 24801139

SN - 1748-1716

VL - 213

SP - 171

EP - 180

JO - Acta Physiologica

JF - Acta Physiologica

IS - 1

ER -

Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition.

Sammanfattning

Ämnesklassifikation (UKÄ)

Tillgång till dokument

Fingeravtryck

Forskningsoutput

Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production

Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse.

Aktiviteter

Mitochondrial Medicine

Summer school on Mitochondrial Physiology

The United Mitochondrial Disease Foundation Symposium 2014

Citera det här