Microbial Translocation Correlates with the Severity of Both HIV-1 and HIV-2 Infections

Salma Nowroozalizadeh, Fredrik Månsson, Zacarias da Silva, Johanna Repits, Braima Dabo, Carla Pereira, Antonio Biague, Jan Albert, Jens Nielsen, Peter Aaby, Eva Maria Fenyö, Hans Norrgren, Birgitta G Holmgren, Marianne Jansson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4(+) T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4(+) T cells, increase in viral load, and defective immune stimuli responsiveness during both HIV type 1 and HIV type 2 infections.
Originalspråkengelska
Sidor (från-till)1150-1154
TidskriftJournal of Infectious Diseases
Volym201
Nummer8
StatusPublished - 2010
Evenemang5th Smögen Symposium on Virology - Smögen, Sverige
Varaktighet: 2009 aug. 202009 aug. 22

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Division of Medical Microbiology (013250400), Infectious Diseases Research Unit (013242010), Division of Infection Medicine (SUS) (013008000)

Ämnesklassifikation (UKÄ)

  • Infektionsmedicin

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