Microglia in neurological diseases: A road map to brain-disease dependent-inflammatory response

Sara Bachiller, Itzia Jiménez-Ferrer, Agnes Paulus, Yiyi Yang, Maria Swanberg, Tomas Deierborg, Antonio Boza-Serrano

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization, trophic neuronal support during development, phagocytosis of apoptotic cells in the developing brain, myelin turnover, control of neuronal excitability, phagocytic debris removal as well as brain protection and repair. Microglial response is pathology dependent and affects to immune, metabolic. In this review, we will shed light on microglial activation depending on the disease context and the influence of factors such as aging, environment or cell-to-cell interaction.

Originalspråkengelska
Artikelnummer488
TidskriftFrontiers in Cellular Neuroscience
Volym12
DOI
StatusPublished - 2018 dec. 18

Ämnesklassifikation (UKÄ)

  • Neurologi

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  • Immunogenetics of Parkinson's disease

    Swanberg, M. & Jimenez-Ferrer, I., 2018 dec. 21, Parkinson’s Disease : Pathogenesis and Clinical Aspects. Stoker, T. B. & Greenland, J. C. (red.). Brisbane (AU): Codon Publications, s. 27-44

    Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverkForskningPeer review

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