TY - JOUR
T1 - Mitochondria and the Brain
T2 - Bioenergetics and Beyond
AU - Belenguer, Pascale
AU - Duarte, João M.N.
AU - Schuck, Patrícia F.
AU - Ferreira, Gustavo C.
PY - 2019
Y1 - 2019
N2 - The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.
AB - The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.
KW - Brain metabolism
KW - Mitochondria
KW - MRS
KW - Neurogenesis
U2 - 10.1007/s12640-019-00061-7
DO - 10.1007/s12640-019-00061-7
M3 - Article
C2 - 31152314
AN - SCOPUS:85066479216
SN - 1029-8428
VL - 36
SP - 219
EP - 238
JO - Neurotoxicity Research
JF - Neurotoxicity Research
IS - 2
ER -