Modelling human rostro-caudal neural patterning with a microfluidic morphogenic gradient

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Sammanfattning

The study of biological mechanisms involved in human fetal brain development requires suitable models. To date, most findings have been acquired from animal models that fail to account for human-specific developmental traits. To counteract this limitation, a novel in vitro model is proposed where human pluripotent stem cells are differentiated into a coherent fetal brain tissue in a gradient forming microfluidic system. Stainings show that the model can be used to investigate the patterning, an important developmental event, of stem cells into forebrain, midbrain and hindbrain. In conclusion, this model could provide a new platform for studying human-specific brain development.

Originalspråkengelska
Titel på värdpublikationMicroTAS 2017
Undertitel på värdpublikationSavannah, Georgia, USA
FörlagChemical and Biological Microsystems Society
Sidor147-148
Antal sidor2
ISBN (elektroniskt)9780692941836
StatusPublished - 2017
Evenemang21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, USA
Varaktighet: 2017 okt. 222017 okt. 26

Publikationsserier

NamnMicroTAS
FörlagThe Chemical and Biological Microsystems Society (CBMS)
Volym2017
ISSN (elektroniskt)1556-5904

Konferens

Konferens21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Land/TerritoriumUSA
OrtSavannah
Period2017/10/222017/10/26

Ämnesklassifikation (UKÄ)

  • Neurovetenskaper
  • Utvecklingsbiologi

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