Sammanfattning
Human plasma samples from 50 wives of fishermen have been analyzed with respect to PCBs. The non-ortho-substituted PCB congeners CB-126 and CB-169 were determined by mass spectrometry in negative ion chemical ionization mode, which demonstrated a limit of detection of 30 fg. The recoveries of the internal standards used for determination of ortho-substituted CBs were approximately 95%. Two methods, one gravimetric and the other based on enzymatic determinations of triglycerides, cholesterol and phospholipids, were compared for the determination of total amount of lipids in the plasma samples; the correlation coefficient was 0.82 and the slope 0.98. For practical reasons, enzymatic determinations are recommended for further use. The total, lipid-adjusted concentrations of PCBs in plasma were influenced by age, total lactation time and consumption of fatty fish from the Baltic Sea.
Originalspråk | engelska |
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Sidor (från-till) | 329-336 |
Tidskrift | Archives of Environmental Contamination and Toxicology |
Volym | 32 |
Nummer | 3 |
DOI | |
Status | Published - 1997 |
Ämnesklassifikation (UKÄ)
- Läkemedelskemi
- Miljömedicin och yrkesmedicin
- Farmakologi och toxikologi