Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

Samuela Pollack, Leif Groop, Emma Ahlqvist, Valeriya Lyssenko, Elisabet Agardh, Lucia Sobrin, Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

22 Citeringar (SciVal)

Sammanfattning

To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). We meta-analyzed across cohorts using inverse-variance weighting, with and without liability threshold modeling of glycemic control and duration of diabetes. Variants with a P value
Originalspråkengelska
Sidor (från-till)441-456
Antal sidor16
TidskriftDiabetes
Volym68
Utgåva2
DOI
StatusPublished - 2019

Bibliografisk information

Export Date: 28 January 2019

Ämnesklassifikation (UKÄ)

  • Endokrinologi och diabetes
  • Medicinsk genetik

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