Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

Petter Säwen, Mohamed Eldeeb, Eva Erlandsson, Trine A. Kristiansen, Cecilia Laterza, Zaal Kokaia, Göran Karlsson, Joan Yuan, Shamit Soneji, Pankaj K. Mandal, Derrick J. Rossi, David Bryder

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

27 Citeringar (SciVal)

Sammanfattning

A hallmark of adult hematopoiesis is the continuous replacement of blood cells with limited lifespans. While active hematopoietic stem cell (HSC) contribution to multilineage hematopoiesis is the foundation of clinical HSC transplantation, recent reports have questioned the physiological contribution of HSCs to normal/steady-state adult hematopoiesis. Here, we use inducible lineage tracing from genetically marked adult HSCs and reveal robust HSC-derived multilineage hematopoiesis. This commences via defined progenitor cells, but varies substantially in between different hematopoietic lineages. By contrast, adult HSC contribution to hematopoietic cells with proposed fetal origins is neglible. Finally, we establish that the HSC contribution to multilineage hematopoiesis declines with increasing age. Therefore, while HSCs are active contributors to native adult hematopoiesis, it appears that the numerical increase of HSCs is a physiologically relevant compensatory mechanism to account for their reduced differentiation capacity with age.

Originalspråkengelska
Artikelnummere41258
TidskrifteLife
Volym7
DOI
StatusPublished - 2018 dec 18

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi
  • Hematologi

Fingeravtryck

Utforska forskningsämnen för ”Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här