Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

O. Klementieva; J. Mathurin; A. Engdahl; R. Freitas; K. Willen; P. Uvdal; L. M. Miller; G. Gouras

doi:10.1109/IRMMW-THz.2018.8510376

Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

O. Klementieva, J. Mathurin, A. Engdahl, R. Freitas, K. Willen, P. Uvdal, L. M. Miller, G. Gouras

Forskningsoutput: Kapitel i bok/rapport/Conference proceeding › Konferenspaper i proceeding › Peer review

Sammanfattning

Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.

Originalspråk	engelska
Titel på värdpublikation	2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018
Förlag	IEEE Computer Society
Volym	2018-September
ISBN (elektroniskt)	9781538638095
DOI	https://doi.org/10.1109/IRMMW-THz.2018.8510376
Status	Published - 2018 okt. 29
Evenemang	43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018 - Nagoya, Japan Varaktighet: 2018 sep. 9 → 2018 sep. 14

Konferens

Konferens	43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018
Land/Territorium	Japan
Ort	Nagoya
Period	2018/09/09 → 2018/09/14

Ämnesklassifikation (UKÄ)

Neurovetenskaper
Medicinsk bildbehandling

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10.1109/IRMMW-THz.2018.8510376

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Klementieva, O., Mathurin, J., Engdahl, A., Freitas, R., Willen, K., Uvdal, P., Miller, L. M., & Gouras, G. (2018). Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice. I 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018 (Vol. 2018-September). Artikel 8510376 IEEE Computer Society. https://doi.org/10.1109/IRMMW-THz.2018.8510376

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title = "Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice",

abstract = "Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.",

author = "O. Klementieva and J. Mathurin and A. Engdahl and R. Freitas and K. Willen and P. Uvdal and Miller, {L. M.} and G. Gouras",

year = "2018",

month = oct,

day = "29",

doi = "10.1109/IRMMW-THz.2018.8510376",

language = "English",

volume = "2018-September",

booktitle = "2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018",

publisher = "IEEE Computer Society",

address = "United States",

note = "43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018 ; Conference date: 09-09-2018 Through 14-09-2018",

}

Klementieva, O, Mathurin, J, Engdahl, A, Freitas, R, Willen, K, Uvdal, P, Miller, LM & Gouras, G 2018, Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice. i 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. vol. 2018-September, 8510376, IEEE Computer Society, 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018, Nagoya, Japan, 2018/09/09. https://doi.org/10.1109/IRMMW-THz.2018.8510376

Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice. / Klementieva, O.; Mathurin, J.; Engdahl, A. et al.
2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. Vol. 2018-September IEEE Computer Society, 2018. 8510376.

Forskningsoutput: Kapitel i bok/rapport/Conference proceeding › Konferenspaper i proceeding › Peer review

TY - GEN

T1 - Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

AU - Klementieva, O.

AU - Mathurin, J.

AU - Engdahl, A.

AU - Freitas, R.

AU - Willen, K.

AU - Uvdal, P.

AU - Miller, L. M.

AU - Gouras, G.

PY - 2018/10/29

Y1 - 2018/10/29

N2 - Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.

AB - Aβ is a class of aggregation-prone proteins, which may misfold into stable, β-sheet rich fibrils. Aβ is linked to the development of synaptic pathology in Alzheimer's disease (AD). However, a main question in the AD field is how Aβ contributes to AD neuropathology? Up to now there is little evidence for protein structural changes in diseased neuron. Our aim is to study the distribution of β-sheet structures in AD transgenic neurons in order to uncover sub-cellular mechanism(s) by which amyloid β-sheet structures are involved in AD pathology.

U2 - 10.1109/IRMMW-THz.2018.8510376

DO - 10.1109/IRMMW-THz.2018.8510376

M3 - Paper in conference proceeding

AN - SCOPUS:85056832774

VL - 2018-September

BT - 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018

PB - IEEE Computer Society

T2 - 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018

Y2 - 9 September 2018 through 14 September 2018

ER -

Klementieva O, Mathurin J, Engdahl A, Freitas R, Willen K, Uvdal P et al. Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice. I 2018 43rd International Conference on Infrared Millimeter and Terahertz Waves, IRMMW-THz 2018. Vol. 2018-September. IEEE Computer Society. 2018. 8510376 doi: 10.1109/IRMMW-THz.2018.8510376

Nano-scale Infrared Imaging of β-sheet Structures in Synaptic Junctions of Primary Neurons Isolated from Transgenic Mice

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