TY - JOUR
T1 - Nationwide Observational Case–Control Study of Risk Factors for Aerococcus Bloodstream Infections, Sweden
AU - Walles, John
AU - Inghammar, Malin
AU - Rasmussen, Magnus
AU - Sunnerhagen, Torgny
PY - 2025/5/1
Y1 - 2025/5/1
N2 - Risk factors for developing bloodstream infections (BSIs) caused by Aerococcus bacteria remain insufficiently examined. In this nationwide case–control study in Sweden, 19 of 23 clinical microbiological laboratories identified patients who had aerococcal BSIs during 2012–2016. We compared each of those index patients with 4 controls matched for age, sex, and county of residence. Overall, 588 episodes of aerococcal BSI occurred over 39.6 million person-years, corresponding to an average incidence of 1.48/100,000 person-years (95% CI 1.37–1.60/100,000 person-years). Most infections developed in men >65 years of age. Aerococcal BSI was associated with neurologic (adjusted odds ratio 2.89 [95% CI 2.26–3.70]) and urologic (adjusted odds ratio 2.15 [95% CI 1.72—2.68]) conditions and previous hospitalization or infection treatment. Our findings support the previously observed predilection for aerococcal BSIs developing in elderly men with urinary tract disorders. Awareness of Aerococcus spp. in patients, especially elderly men, will be needed to manage invasive infections.
AB - Risk factors for developing bloodstream infections (BSIs) caused by Aerococcus bacteria remain insufficiently examined. In this nationwide case–control study in Sweden, 19 of 23 clinical microbiological laboratories identified patients who had aerococcal BSIs during 2012–2016. We compared each of those index patients with 4 controls matched for age, sex, and county of residence. Overall, 588 episodes of aerococcal BSI occurred over 39.6 million person-years, corresponding to an average incidence of 1.48/100,000 person-years (95% CI 1.37–1.60/100,000 person-years). Most infections developed in men >65 years of age. Aerococcal BSI was associated with neurologic (adjusted odds ratio 2.89 [95% CI 2.26–3.70]) and urologic (adjusted odds ratio 2.15 [95% CI 1.72—2.68]) conditions and previous hospitalization or infection treatment. Our findings support the previously observed predilection for aerococcal BSIs developing in elderly men with urinary tract disorders. Awareness of Aerococcus spp. in patients, especially elderly men, will be needed to manage invasive infections.
U2 - 10.3201/eid3105.240424
DO - 10.3201/eid3105.240424
M3 - Article
SN - 1080-6040
VL - 31
SP - 887
EP - 898
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 5
ER -