Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.

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Sammanfattning

Autoantibodies (A) against Neuropeptide Y (NPY), was reported in 9% newly diagnosed type 1 diabetes (T1D) patients. A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. We aimed to determine: (i) the influence of autoantibodies to leucine neuropeptide Y (NPY-LA) and autoantibodies to proline neuropeptide Y (NPY-PA) on the diagnostic sensitivity of type 1 diabetes (T1D), (ii) the association of NPYA with major islet autoantibodies, and (iii) the association of NPYA with HLA-DQ genotypes in newly diagnosed T1D patients.
Originalspråkengelska
Sidor (från-till)621-628
TidskriftPediatric Diabetes
Volym16
Nummer8
DOI
StatusPublished - 2015

Ämnesklassifikation (UKÄ)

  • Endokrinologi och diabetes
  • Pediatrik

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