Neuropeptide Y: prejunctional inhibition of vagally induced contractions in the guinea pig trachea

L Grundemar; Erik Widmark; B Waldeck; R Håkanson

doi:10.1016/0167-0115(88)90231-5

Neuropeptide Y: prejunctional inhibition of vagally induced contractions in the guinea pig trachea

L Grundemar, Erik Widmark, B Waldeck, R Håkanson

Avdelningen för klinisk kemi och farmakologi

Astra Draco AB

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.

Originalspråk	engelska
Sidor (från-till)	309-313
Tidskrift	Regulatory Peptides
Volym	23
Nummer	3
DOI	https://doi.org/10.1016/0167-0115(88)90231-5
Status	Published - 1988 dec.

Ämnesklassifikation (UKÄ)

Farmakologi och toxikologi

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10.1016/0167-0115(88)90231-5

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title = "Neuropeptide Y: prejunctional inhibition of vagally induced contractions in the guinea pig trachea",

abstract = "The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.",

keywords = "Animals, Carbachol/pharmacology, Dose-Response Relationship, Drug, Electric Stimulation, Guinea Pigs, Male, Muscle Contraction/drug effects, Muscle, Smooth/drug effects, Neuropeptide Y/pharmacology, Trachea/drug effects, Vagus Nerve/drug effects",

author = "L Grundemar and Erik Widmark and B Waldeck and R H{\aa}kanson",

year = "1988",

month = dec,

doi = "10.1016/0167-0115(88)90231-5",

language = "English",

volume = "23",

pages = "309--313",

journal = "Regulatory Peptides",

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TY - JOUR

T1 - Neuropeptide Y

T2 - prejunctional inhibition of vagally induced contractions in the guinea pig trachea

AU - Grundemar, L

AU - Widmark, Erik

AU - Waldeck, B

AU - Håkanson, R

PY - 1988/12

Y1 - 1988/12

N2 - The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.

AB - The effects of neuropeptide Y (NPY) on the contractile response to vagus nerve stimulation at different frequencies was studied in an isolated tracheal tube preparation from guinea pig. NPY had no effect on basal smooth muscle tension or on the contractile effect of carbachol, but inhibited vagally induced contractions in a concentration-dependent manner with a greater inhibition at low frequencies than at high. We suggest that the effect is exerted prejunctionally.

KW - Animals

KW - Carbachol/pharmacology

KW - Dose-Response Relationship, Drug

KW - Electric Stimulation

KW - Guinea Pigs

KW - Male

KW - Muscle Contraction/drug effects

KW - Muscle, Smooth/drug effects

KW - Neuropeptide Y/pharmacology

KW - Trachea/drug effects

KW - Vagus Nerve/drug effects

U2 - 10.1016/0167-0115(88)90231-5

DO - 10.1016/0167-0115(88)90231-5

M3 - Article

C2 - 3238053

SN - 0167-0115

VL - 23

SP - 309

EP - 313

JO - Regulatory Peptides

JF - Regulatory Peptides

IS - 3

ER -

Neuropeptide Y: prejunctional inhibition of vagally induced contractions in the guinea pig trachea

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Ämnesklassifikation (UKÄ)

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