Neutrophil extracellular traps in colorectal cancer progression and metastasis

Umama Khan, Sabrina Chowdhury, Md Morsaline Billah, Kazi Mohammed Didarul Islam, Henrik Thorlacius, Milladur Rahman

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy.

Originalspråkengelska
Artikelnummer7260
TidskriftInternational Journal of Molecular Sciences
Volym22
Nummer14
DOI
StatusPublished - 2021 juli 2

Bibliografisk information

Funding Information:
Cancerfonden (19 0428 Pj). Acknowledgments: Graphical images were prepared using digital contents from SERVIER MEDICAL ART (https://smart.servier.com) covered by CC BY license.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi
  • Cell- och molekylärbiologi

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