Non-reversible heat-induced gelation of a biocompatible Fmoc-hexapeptide in water

Jonathan P. Wojciechowski, Adam D. Martin, Eric Y. Du, Christopher J. Garvey, Robert E. Nordon, Pall Thordarson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Hydrogel materials which respond to changes in temperature are widely applicable for injectable drug delivery or tissue engineering applications. Here, we report the unsual heat-induced gelation behaviour of a low molecular weight gelator based on an Fmoc-hexapeptide, Fmoc-GFFRGD. We show that Fmoc-GFFRGD forms kinetically stable fibres when mixed with divalent cations (e.g. Ca2+). Gelation of the mixture occurs upon heating of the mixture which enables electrostatic screening by the divalent cations and hydrophobic collapse of the fibres to give a self-supporting hydrogel network that shows good biocompatibility with L929 fibroblast cells. This work highlights a unique mechanism to initiate heat-induced gelation which should find opportunities as a gelation trigger for injectable hydrogels or fundamental self-assembly applications.

Originalspråkengelska
Sidor (från-till)8262-8267
Antal sidor6
TidskriftNanoscale
Volym12
Nummer15
DOI
StatusPublished - 2020

Ämnesklassifikation (UKÄ)

  • Biokemi och molekylärbiologi

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