Normalization of Magnetic Field Effects: Towards Quantitative Magnetomotive Ultrasound Imaging

Maria Evertsson, Magnus Cinthio, Sarah Fredriksson, Fredrik Olsson, Hans W Persson, Tomas Jansson

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceedingPeer review

Sammanfattning

In magnetomotive ultrasound (MMUS) imaging superparamagnetic iron oxide nanoparticles (NP) are used as contrast agents and a time-varying external magnetic field acts to move the particles and thereby the nanoparticle-laden tissue. Recently we proposed a frequency and phase sensitive algorithm to reduce motion artifacts. However, the method is not quantitative as the particle movement induced is dependent not only on the field strength, but also on the field gradient, plus material parameters. Here we assess the measured nanoparticle movement across the image plane in comparison with simulations of the magnetic force, to evaluate the potential for image normalization of magnetic field effects. We found that the movement decreased with distance to the iron core tip, from which the magnetic field was extending, and approaches zero at the transducer face. This finding did not coincide with the simulation and may make it difficult to enable quantification. The coefficient of variation between measurements on the homogeneous phantom was typically in the order of 15% for all frequencies, indicating the expected accuracy for quantitative measurements.
Originalspråkengelska
Titel på värdpublikation2011 IEEE International Ultrasonics Symposium (IUS)
FörlagIEEE - Institute of Electrical and Electronics Engineers Inc.
Sidor775-778
ISBN (tryckt)978-1-4577-1253-1
DOI
StatusPublished - 2012
EvenemangIEEE International Ultrasonics Symposium (IUS), 2011 - Orlando, FL, USA
Varaktighet: 2011 okt. 182011 okt. 21

Konferens

KonferensIEEE International Ultrasonics Symposium (IUS), 2011
Land/TerritoriumUSA
OrtOrlando, FL
Period2011/10/182011/10/21

Ämnesklassifikation (UKÄ)

  • Medicinteknik

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