Novel Aspects Pertaining to the Relationship of Waldenstrom's Macroglobulinemia, IgM Monoclonal Gammopathy of Undetermined Significance, Polyclonal Gammopathy, and Hypoglobulinemia

Mary L. McMaster, Sigurdur Y. Kristinsson, Ingemar Turesson, Magnus Bjorkholm, Ola Landgren

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceedingPeer review

14 Citeringar (SciVal)

Sammanfattning

Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown. Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have demonstrated an increased frequency of IgM MGUS compared with the general population and have provided new data suggesting that the phenotypic spectrum might also include polyclonal gammopathy and hypoglobulinemia. While the preponderance of immunoglobulin abnormalities in relatives of WM cases involves IgM, other immunoglobulin types (IgG and IgA) might also be affected. Large collaborative studies are needed to confirm these findings, which present an opportunity to define the earliest lesion(s) in the WM oncogenic pathway.
Originalspråkengelska
Titel på värdpublikationClinical Lymphoma & Myeloma
FörlagCIG Media Group
Sidor19-22
Volym9
DOI
StatusPublished - 2009
Evenemang5th International Workshop on Waldenstroms Macroglobulinemia - Stockholm, SWEDEN
Varaktighet: 2008 okt. 152008 okt. 19

Publikationsserier

Namn
Nummer1
Volym9
ISSN (tryckt)1557-9190

Konferens

Konferens5th International Workshop on Waldenstroms Macroglobulinemia
Period2008/10/152008/10/19

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

Ämnesklassifikation (UKÄ)

  • Klinisk medicin

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