TY - JOUR
T1 - Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.
AU - Vikingsson, Svante
AU - Andersson, David
AU - Almer, Sven
AU - Peterson, Curt
AU - Hindorf, Ulf
PY - 2014
Y1 - 2014
N2 - The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.
AB - The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.
U2 - 10.1016/j.crohns.2014.08.009
DO - 10.1016/j.crohns.2014.08.009
M3 - Article
SN - 1873-9946
VL - 8
SP - 1702
EP - 1709
JO - Journal of Crohn's & Colitis
JF - Journal of Crohn's & Colitis
IS - 12
ER -