Novel distribution of the secretory leucocyte proteinase inhibitor in kidney

Sophie Ohlsson, Irena Ljungkrantz, Kjell Ohlsson, Mårten Segelmark, Jörgen Wieslander

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

20 !!Citations (SciVal)

Sammanfattning

The secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. The presence of SLPI in renal tubuli cells was demonstrated using immunohistochemistry and, by means of in situ hybridisation on human renal biopsies, we were able to demonstrate SLPI production. In various inflammatory conditions in the kidneys, the protease-antiprotease balance is disturbed. For this reason, as well as the possible role in the defence against ascending urinary tract infections, it is interesting to establish a source of SLPI in renal tubuli cells.
Originalspråkengelska
Sidor (från-till)347-350
TidskriftMediators of Inflammation
Volym10
Utgåva6
DOI
StatusPublished - 2001

Ämnesklassifikation (UKÄ)

  • Reumatologi och inflammation

Fingeravtryck

Utforska forskningsämnen för ”Novel distribution of the secretory leucocyte proteinase inhibitor in kidney”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här