Novel insights in drug metabolism by MS imaging.

Yutaka Sugihara, Ken-ichi Watanabe, Ákos Végvári

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review


During the last decade, lateral and temporal localization of drug compounds and their metabolites have been demonstrated and dynamically developed using MS imaging. The pharmaceutical industry has recognized the potential of the technology that provides simultaneous distribution and quantitative data. In this review, we present the latest technological achievements and summarize applications of drug imaging focusing on studies about metabolites by MALDI-MS imaging. We also introduce potential areas with pharmaceutical applications that are currently under exploration, including pharmacological, toxicological characterizations and metabolic enzyme localization in comparison with drug and metabolite distribution.
Sidor (från-till)575-588
StatusPublished - 2016

Ämnesklassifikation (UKÄ)

  • Farmakologi och toxikologi


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