TY - JOUR
T1 - Occupational noise exposure and risk of incident stroke
T2 - a pooled study of five Scandinavian cohorts
AU - Thacher, Jesse D.
AU - Roswall, Nina
AU - Lissåker, Claudia
AU - Aasvang, Gunn Marit
AU - Albin, Maria
AU - Andersson, Eva M.
AU - Engström, Gunnar
AU - Eriksson, Charlotta
AU - Hvidtfeldt, Ulla Arthur
AU - Ketzel, Matthias
AU - Khan, Jibran
AU - Lanki, Timo
AU - Ljungman, Petter L.S.
AU - Mattisson, Kristoffer
AU - Molnar, Peter
AU - Raaschou-Nielsen, Ole
AU - Oudin, Anna
AU - Overvad, Kim
AU - Petersen, Sesilje Bondo
AU - Pershagen, Göran
AU - Poulsen, Aslak Harbo
AU - Pyko, Andrei
AU - Rizzuto, Debora
AU - Rosengren, Annika
AU - Schioler, Linus
AU - Sjöström, Mattias
AU - Stockfelt, Leo
AU - Tiittanen, Pekka
AU - Sallsten, Gerd
AU - Ögren, Mikael
AU - Selander, Jenny
AU - Sorensen, Mette
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2022
Y1 - 2022
N2 - Objectives: To investigate the association between occupational noise exposure and stroke incidence in a pooled study of five Scandinavian cohorts (NordSOUND). Methods: We pooled and harmonised data from five Scandinavian cohorts resulting in 78 389 participants. We obtained job data from national registries or questionnaires and recoded these to match a job-exposure matrix developed in Sweden, which specified the annual average daily noise exposure in five exposure classes (LAeq8h): <70, 70-74, 75-79, 80-84, ≥85 dB(A). We identified residential address history and estimated 1-year average road traffic noise at baseline. Using national patient and mortality registers, we identified 7777 stroke cases with a median follow-up of 20.2 years. Analyses were conducted using Cox proportional hazards models adjusting for individual and area-level potential confounders. Results: Exposure to occupational noise at baseline was not associated with overall stroke in the fully adjusted models. For ischaemic stroke, occupational noise was associated with HRs (95% CI) of 1.08 (0.98 to 1.20), 1.09 (0.97 to 1.24) and 1.06 (0.92 to 1.21) in the 75-79, 80-84 and ≥85 dB(A) exposure groups, compared with <70 dB(A), respectively. In subanalyses using time-varying occupational noise exposure, we observed an indication of higher stroke risk among the most exposed (≥85 dB(A)), particularly when restricting analyses to people exposed to occupational noise within the last year (HR: 1.27; 95% CI: 0.99 to 1.63). Conclusions: We found no association between occupational noise and risk of overall stroke after adjustment for confounders. However, the non-significantly increased risk of ischaemic stroke warrants further investigation.
AB - Objectives: To investigate the association between occupational noise exposure and stroke incidence in a pooled study of five Scandinavian cohorts (NordSOUND). Methods: We pooled and harmonised data from five Scandinavian cohorts resulting in 78 389 participants. We obtained job data from national registries or questionnaires and recoded these to match a job-exposure matrix developed in Sweden, which specified the annual average daily noise exposure in five exposure classes (LAeq8h): <70, 70-74, 75-79, 80-84, ≥85 dB(A). We identified residential address history and estimated 1-year average road traffic noise at baseline. Using national patient and mortality registers, we identified 7777 stroke cases with a median follow-up of 20.2 years. Analyses were conducted using Cox proportional hazards models adjusting for individual and area-level potential confounders. Results: Exposure to occupational noise at baseline was not associated with overall stroke in the fully adjusted models. For ischaemic stroke, occupational noise was associated with HRs (95% CI) of 1.08 (0.98 to 1.20), 1.09 (0.97 to 1.24) and 1.06 (0.92 to 1.21) in the 75-79, 80-84 and ≥85 dB(A) exposure groups, compared with <70 dB(A), respectively. In subanalyses using time-varying occupational noise exposure, we observed an indication of higher stroke risk among the most exposed (≥85 dB(A)), particularly when restricting analyses to people exposed to occupational noise within the last year (HR: 1.27; 95% CI: 0.99 to 1.63). Conclusions: We found no association between occupational noise and risk of overall stroke after adjustment for confounders. However, the non-significantly increased risk of ischaemic stroke warrants further investigation.
KW - epidemiology
KW - noise
KW - public health
U2 - 10.1136/oemed-2021-108053
DO - 10.1136/oemed-2021-108053
M3 - Article
C2 - 35450950
AN - SCOPUS:85130847985
SN - 1351-0711
VL - 79
SP - 594
EP - 601
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
IS - 9
ER -