On the effect of flavonoids and dietary fibre in lingonberries on atherosclerotic plaques, lipid profiles and gut microbiota composition in Apoe-/- mice

Jiyun Liu, Mohammed E Hefni, Cornelia M Witthöft, Maria Bergström, Stephen Burleigh, Margareta Nyman, Frida Hållenius

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

It has not been clarified whether the anti-atherosclerotic effect of lingonberry can be ascribed to its content of flavonoids or dietary fibre or both. The aim of this study was to evaluate the metabolic effects of whole lingonberries compared with isolated flavonoid and fibre fractions on atherosclerotic plaques, plasma lipid profiles, gut microbiota and microbiota-dependent metabolites in an Apoe–/– mouse model. Mice fed whole lingonberries showed the lowest amount of atherosclerotic plaques, while mice fed the fibre fraction had the highest formation of caecal butyric acid. Flavonoids, rather than dietary fibre, were suggested to be the components that favour proliferation of Akkermansia, as judged by the lowest abundance of this bacterium in mice fed the fibre fraction. All groups fed lingonberry diets had both, lower Firmicutes/Bacteroidetes ratios and creatinine concentrations, compared with the control. To conclude, different components in lingonberries are associated with different physiological effects in Apoe–/– mice.
Originalspråkengelska
Sidor (från-till)1080-1090
Antal sidor11
TidskriftInternational Journal of Food Sciences and Nutrition
Volym73
Nummer8
Tidigt onlinedatum2022 aug. 5
DOI
StatusPublished - 2022

Ämnesklassifikation (UKÄ)

  • Näringslära
  • Livsmedelsvetenskap

Fingeravtryck

Utforska forskningsämnen för ”On the effect of flavonoids and dietary fibre in lingonberries on atherosclerotic plaques, lipid profiles and gut microbiota composition in Apoe-/- mice”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här