Optimization of PIXE-sensitivity for detection of Ti in thin human skin sections

Jan Pallon; Mats Garmer; Vaida Auzelyte; Mikael Elfman; Per Kristiansson; Klas Malmqvist; Christer Nilsson; Asad Shariff; Marie Wegdén

doi:10.1016/j.nimb.2005.01.070

Optimization of PIXE-sensitivity for detection of Ti in thin human skin sections

Jan Pallon, Mats Garmer, Vaida Auzelyte, Mikael Elfman, Per Kristiansson, Klas Malmqvist, Christer Nilsson, Asad Shariff, Marie Wegdén

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Modern sunscreens contain particles like TiO2 having sizes of 25-70 nm and acting as a reflecting substance. For cosmetic reasons the particle size is minimized. Questions have been raised to what degree these nano particles penetrate the skin barrier, and how they do affect the human. The EU funded project "Quality of skin as a barrier to ultra-fine particles" - NANODERM has started with the purpose to evaluate the possible risks of TiO2 penetration into vital skin layers. The purpose of the work presented here was to find the optimal conditions for micro-PIXE analysis of Ti in thin skin sections. In the skin region where Ti is expected to be found, the naturally occurring major elements phosphorus, chlorine, sulphur and potassium have steep gradients and thus influence the X-ray background in a non-predictable manner. Based on experimental studies of Ti-exposed human skin sections using proton energies ranging from 1.8-2.55 MeV, the corresponding PIXE detection limits for Ti were calculated. The energy that was found to be the most favourable, 1.9 MeV, was then selected for future studies.

Originalspråk	engelska
Sidor (från-till)	274-279
Tidskrift	Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Volym	231
Nummer	1-4
DOI	https://doi.org/10.1016/j.nimb.2005.01.070
Status	Published - 2005

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The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007)

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10.1016/j.nimb.2005.01.070

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Pallon, J., Garmer, M., Auzelyte, V., Elfman, M., Kristiansson, P., Malmqvist, K., Nilsson, C., Shariff, A., & Wegdén, M. (2005). Optimization of PIXE-sensitivity for detection of Ti in thin human skin sections. Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 231(1-4), 274-279. https://doi.org/10.1016/j.nimb.2005.01.070

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abstract = "Modern sunscreens contain particles like TiO2 having sizes of 25-70 nm and acting as a reflecting substance. For cosmetic reasons the particle size is minimized. Questions have been raised to what degree these nano particles penetrate the skin barrier, and how they do affect the human. The EU funded project {"}Quality of skin as a barrier to ultra-fine particles{"} - NANODERM has started with the purpose to evaluate the possible risks of TiO2 penetration into vital skin layers. The purpose of the work presented here was to find the optimal conditions for micro-PIXE analysis of Ti in thin skin sections. In the skin region where Ti is expected to be found, the naturally occurring major elements phosphorus, chlorine, sulphur and potassium have steep gradients and thus influence the X-ray background in a non-predictable manner. Based on experimental studies of Ti-exposed human skin sections using proton energies ranging from 1.8-2.55 MeV, the corresponding PIXE detection limits for Ti were calculated. The energy that was found to be the most favourable, 1.9 MeV, was then selected for future studies.",

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author = "Jan Pallon and Mats Garmer and Vaida Auzelyte and Mikael Elfman and Per Kristiansson and Klas Malmqvist and Christer Nilsson and Asad Shariff and Marie Wegd{\'e}n",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007)",

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doi = "10.1016/j.nimb.2005.01.070",

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Pallon, J, Garmer, M, Auzelyte, V, Elfman, M , Kristiansson, P, Malmqvist, K, Nilsson, C, Shariff, A & Wegdén, M 2005, 'Optimization of PIXE-sensitivity for detection of Ti in thin human skin sections', Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, vol. 231, nr. 1-4, s. 274-279. https://doi.org/10.1016/j.nimb.2005.01.070

TY - JOUR

T1 - Optimization of PIXE-sensitivity for detection of Ti in thin human skin sections

AU - Pallon, Jan

AU - Garmer, Mats

AU - Auzelyte, Vaida

AU - Elfman, Mikael

AU - Kristiansson, Per

AU - Malmqvist, Klas

AU - Nilsson, Christer

AU - Shariff, Asad

AU - Wegdén, Marie

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007)

PY - 2005

Y1 - 2005

N2 - Modern sunscreens contain particles like TiO2 having sizes of 25-70 nm and acting as a reflecting substance. For cosmetic reasons the particle size is minimized. Questions have been raised to what degree these nano particles penetrate the skin barrier, and how they do affect the human. The EU funded project "Quality of skin as a barrier to ultra-fine particles" - NANODERM has started with the purpose to evaluate the possible risks of TiO2 penetration into vital skin layers. The purpose of the work presented here was to find the optimal conditions for micro-PIXE analysis of Ti in thin skin sections. In the skin region where Ti is expected to be found, the naturally occurring major elements phosphorus, chlorine, sulphur and potassium have steep gradients and thus influence the X-ray background in a non-predictable manner. Based on experimental studies of Ti-exposed human skin sections using proton energies ranging from 1.8-2.55 MeV, the corresponding PIXE detection limits for Ti were calculated. The energy that was found to be the most favourable, 1.9 MeV, was then selected for future studies.

AB - Modern sunscreens contain particles like TiO2 having sizes of 25-70 nm and acting as a reflecting substance. For cosmetic reasons the particle size is minimized. Questions have been raised to what degree these nano particles penetrate the skin barrier, and how they do affect the human. The EU funded project "Quality of skin as a barrier to ultra-fine particles" - NANODERM has started with the purpose to evaluate the possible risks of TiO2 penetration into vital skin layers. The purpose of the work presented here was to find the optimal conditions for micro-PIXE analysis of Ti in thin skin sections. In the skin region where Ti is expected to be found, the naturally occurring major elements phosphorus, chlorine, sulphur and potassium have steep gradients and thus influence the X-ray background in a non-predictable manner. Based on experimental studies of Ti-exposed human skin sections using proton energies ranging from 1.8-2.55 MeV, the corresponding PIXE detection limits for Ti were calculated. The energy that was found to be the most favourable, 1.9 MeV, was then selected for future studies.

KW - skin

KW - nuclear microprobe

KW - PIXE

KW - detection limits

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DO - 10.1016/j.nimb.2005.01.070

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SN - 0168-583X

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JO - Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

IS - 1-4

ER -

Optimization of PIXE-sensitivity for detection of Ti in thin human skin sections

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