Pattern, timing and predictors of recurrence after surgical resection of chromophobe renal cell carcinoma

Joana B. Neves, Leyre Vanaclocha Saiz, Yasmin Abu-Ghanem, Marta Marchetti, My Anh Tran-Dang, Soha El-Sheikh, Ravi Barod, Christian Beisland, Umberto Capitanio, David Cullen, Tobias Klatte, Börje Ljungberg, Faiz Mumtaz, Prasad Patki, Grant D. Stewart, Saeed Dabestani, Maxine G.B. Tran, Axel Bex, the RECUR consortium

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

1 Citering (SciVal)

Sammanfattning

Purpose: Currently there are no specific guidelines for the post-operative follow-up of chromophobe renal cell carcinoma (chRCC). We aimed to evaluate the pattern, location and timing of recurrence after surgery for non-metastatic chRCC and establish predictors of recurrence and cancer-specific death. Methods: Retrospective analysis of consecutive surgically treated non-metastatic chRCC cases from the Royal Free London NHS Foundation Trust (UK, 2015–2019) and the international collaborative database RECUR (15 institutes, 2006–2011). Kaplan–Meier curves were plotted. The association between variables of interest and outcomes were analysed using univariate and multivariate Cox proportional hazards regression models with shared frailty for data source. Results: 295 patients were identified. Median follow-up was 58 months. The five and ten-year recurrence-free survival rates were 94.3% and 89.2%. Seventeen patients (5.7%) developed recurrent disease, 13 (76.5%) with distant metastases. 54% of metastatic disease diagnoses involved a single organ, most commonly the bone. Early recurrence (< 24 months) was observed in 8 cases, all staged ≥ pT2b. 30 deaths occurred, of which 11 were attributed to chRCC. Sarcomatoid differentiation was rare (n = 4) but associated with recurrence and cancer-specific death on univariate analysis. On multivariate analysis, UICC/AJCC T-stage ≥ pT2b, presence of coagulative necrosis, and positive surgical margins were predictors of recurrence and cancer-specific death. Conclusion: Recurrence and death after surgically resected chRCC are rare. For completely excised lesions ≤ pT2a without coagulative necrosis or sarcomatoid features, prognosis is excellent. These patients should be reassured and follow-up intensity curtailed.

Originalspråkengelska
Sidor (från-till)3823-3831
TidskriftWorld Journal of Urology
Volym39
Utgåva10
Tidigt onlinedatum2021
DOI
StatusPublished - 2021

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi
  • Urologi och njurmedicin

Fingeravtryck

Utforska forskningsämnen för ”Pattern, timing and predictors of recurrence after surgical resection of chromophobe renal cell carcinoma”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här