Peptide-Oleate Complexes Create Novel Membrane-Bound Compartments

Jesper S. Hansen, Tuan Hiep Tran, Michele Cavalera, Sanchari Paul, Arunima Chaudhuri, Karin Lindkvist-Petersson, James C.S. Ho, Catharina Svanborg

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

A challenging question in evolutionary theory is the origin of cell division and plausible molecular mechanisms involved. Here, we made the surprising observation that complexes formed by short alpha-helical peptides and oleic acid can create multiple membrane-enclosed spaces from a single lipid vesicle. The findings suggest that such complexes may contain the molecular information necessary to initiate and sustain this process. Based on these observations, we propose a new molecular model to understand protocell division.

Originalspråkengelska
Sidor (från-till)3083-3093
Antal sidor11
TidskriftMolecular biology and evolution
Volym37
Nummer11
DOI
StatusPublished - 2020 nov. 1

Ämnesklassifikation (UKÄ)

  • Biokemi och molekylärbiologi

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