Persistent production of neurons from adult brain stem cells during recovery after stroke.

Per Thored, Andreas Arvidsson, Emanuele Cacci, Henrik Ahlenius, Therese Kallur, Vladimer Darsalia, Christine Ekdahl Clementson, Zaal Kokaia, Olle Lindvall

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons toward the ischemic damage is regulated by stromal cell-derived factor-la and its receptor CXCR4. These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke.
Originalspråkengelska
Sidor (från-till)739-747
TidskriftStem Cells
Volym24
Nummer3
DOI
StatusPublished - 2006

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Restorative Neurology (0131000160), Stem Cell Center (013041110), Neurology, Lund (013027000)

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi

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