Pharmacokinetic study of a systemically administered novel liposomal Temoporfin formulation in an animal tumor model

Jenny Svensson, Ann Johansson, Niels Bendsöe, Susanna Grafe, Tilmann Trebst, Stefan Andersson-Engels, Katarina Svanberg

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceedingForskningPeer review

1 !!Citation (SciVal)
135 Nedladdningar (Pure)

Sammanfattning

Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (international generic name Temoporfin) is a potent photosensitizer used for photodynamic therapy (PDT). In this study the pharmacokinetics of a systemically administered novel lipid formulation of Temoporfin in a murine tumor model has been investigated. Fluorescence spectroscopy measurements were performed at several time intervals following drug administration, yielding information on the Temoporfin concentration within excised internal organs as a function of time after injection. Both point-monitoring and imaging setups were used. The acquired fluorescence data were correlated to the concentration of Temoporfin obtained with High Performance Liquid Chromatography (HPLC). There was a significant correlation between the fluorescence methods and HPLC for most organs investigated. The pharmacokinetics of this new liposomal formulation of Temoporfin exhibited a rather flat temporal profile in the time interval 2-8 hours in this study.
Originalspråkengelska
Titel på gästpublikationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
FörlagSPIE
SidorT4270-T4270
Volym6427
DOI
StatusPublished - 2007
EvenemangOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI - San Jose, CA, USA
Varaktighet: 2007 jan 202007 jan 21

Publikationsserier

Namn
Volym6427
ISSN (tryckt)1605-7422
ISSN (elektroniskt)1042-4687

Konferens

KonferensOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
Land/TerritoriumUSA
OrtSan Jose, CA
Period2007/01/202007/01/21

Ämnesklassifikation (UKÄ)

  • Dermatologi och venereologi

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