Photoacoustic imaging of the spatial distribution of oxygen saturation in an ischemia-reperfusion model in humans

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Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the advantages of optical and ultrasound imaging to produce hyperspectral images of the tissue. The feasibility of measuring oxygen saturation (sO2) with PAI has been demonstrated pre-clinically, but has limited use in humans under conditions of ischemia and reperfusion. As an important step towards making PAI clinically available, we present a study in which PAI was used to estimate the spatial distribution of sO2 in vivo during and after occlusion of the finger of eight healthy volunteers. The results were compared with a commercial oxygen saturation monitor based on diffuse reflectance spectroscopy. We here describe the capability of PAI to provide spatially resolved picture of the evolution of sO2 during ischemia following vascular occlusion of a finger, demonstrating the clinical viability of PAI as a non-invasive diagnostic tool for diseases indicated by impaired microvascularization.

Sidor (från-till)2484-2495
TidskriftBiomedical Optics Express
StatusPublished - 2021

Bibliografisk information

Funding Information:
Funding. Swedish Government for Clinical Research (ALF); Skånes universitetssjukhus; Region Kronoberg; Skåne County Council’s Research and Development Foundation; Lund University Grant for Research Infrastructure; Swedish Cancer Foundation; Stiftelsen Kronprinsessan Margaretas Arbetsnämnd för Synskadade; Stiftelsen för Synskadade i f.d. Malmöhus län; Lund Laser Center; IngaBritt och Arne Lundbergs Forskningsstiftelse; Cronqvist Foundation; Sveriges Läkarförbund.

Publisher Copyright:
© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.

Copyright 2021 Elsevier B.V., All rights reserved.

Ämnesklassifikation (UKÄ)

  • Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)


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