Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery

Marcelo Soto Thompson, Stefan Andersson-Engels, Sune Svanberg, Thomas Johansson, Sara Pålsson, Niels Bendsöe, A Derjabo, J Kapostins, U Stenram, J Spigulis, Katarina Svanberg

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results.
Originalspråkengelska
Sidor (från-till)411-424
TidskriftJournal of Environmental Pathology and Toxicology
Volym25
Nummer1-2
StatusPublished - 2006

Ämnesklassifikation (UKÄ)

  • Atom- och molekylfysik och optik

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