Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long-lived individuals

Valentina Siino, Ashfaq Ali, Giulia Accardi, Anna Aiello, Mattia E. Ligotti, Sergio Mosquim Junior, Giuseppina Candore, Calogero Caruso, Fredrik Levander, Sonya Vasto

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging.

Originalspråkengelska
Artikelnummere13684
TidskriftAging Cell
Volym21
Nummer9
DOI
StatusPublished - 2022 sep.

Ämnesklassifikation (UKÄ)

  • Klinisk laboratoriemedicin

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