Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.

Mona Bungum, Aleksander Giwercman, Leif Bungum, Peter Humaidan, Hamideh Rastkhani, Yvonne Giwercman

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

14 Citeringar (SciVal)

Sammanfattning

The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).
Originalspråkengelska
Sidor (från-till)277-279
TidskriftFertility and Sterility
Volym93
Utgåva1
DOI
StatusPublished - 2010

Ämnesklassifikation (UKÄ)

  • Reproduktionsmedicin och gynekologi

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