TY - JOUR
T1 - Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition
AU - Kliemann, Nathalie
AU - Murphy, Neil
AU - Viallon, Vivian
AU - Freisling, Heinz
AU - Tsilidis, Konstantinos K.
AU - Rinaldi, Sabina
AU - Mancini, Francesca R.
AU - Fagherazzi, Guy
AU - Boutron-Ruault, Marie Christine
AU - Boeing, Heiner
AU - Schulze, Matthias B.
AU - Masala, Giovanna
AU - Krogh, Vittorio
AU - Sacerdote, Carlotta
AU - de Magistris, Maria S.
AU - Bueno-de-Mesquita, Bas
AU - Weiderpass, Elisabete
AU - Kühn, Tilman
AU - Kaaks, Rudolf
AU - Jakszyn, Paula
AU - Redondo-Sánchez, Daniel
AU - Amiano, Pilar
AU - Chirlaque, Maria Dolores
AU - Gurrea, Aurelio B.
AU - Ericson, Ulrica
AU - Drake, Isabel
AU - Nøst, Therese H.
AU - Aune, Dagfinn
AU - May, Anne M.
AU - Tjønneland, Anne
AU - Dahm, Christina C.
AU - Overvad, Kim
AU - Tumino, Rosario
AU - Quirós, Jose R.
AU - Trichopoulou, Antonia
AU - Karakatsani, Anna
AU - La Vecchia, Carlo
AU - Nilsson, Lena M.
AU - Riboli, Elio
AU - Huybrechts, Inge
AU - Gunter, Marc J.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.
AB - Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.
KW - basal metabolic rate
KW - cancer
KW - metabolic disorder
KW - obesity
U2 - 10.1002/ijc.32753
DO - 10.1002/ijc.32753
M3 - Article
C2 - 31652358
AN - SCOPUS:85075421128
SN - 0020-7136
VL - 147
SP - 648
EP - 661
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 3
ER -
