Predictive biomarkers in radioresistant rectal cancer: A systematic review

Anna Slipsager, Sofie N. Henrichsen, Ursula G. Falkmer, Karen Dybkær, Mattias Belting, Laurids Poulsen

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review


Background and aims: The treatment of locally advanced rectal cancer often consists of neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of patients show no response to this neoadjuvant chemoradiotherapy. This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer. Method: Through a systematic literature search, 125 papers were included and analyzed using ROBINS-I, a Cochrane risk of bias tool for non-randomized studies of interventions. Both statistically significant and nonsignificant biomarkers were identified. Biomarkers mentioned more than once in the results or biomarkers with a low or moderate risk of bias were included as the final results. Results: Thirteen unique biomarkers, three genetic signatures, one specific pathway, and two combinations of two or four biomarkers were identified. In particular, the connection between HMGCS2, COASY, and PI3K-pathway seems promising. Future scientific research should focus on further validating these genetic resistance markers.

TidskriftCritical Reviews in Oncology/Hematology
StatusPublished - 2023

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi


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