Prevalence and classification of meniscal calcifications in the human knee

Bijay Ratna Shakya, Ville-Pauli Karjalainen, Iida Hellberg, Mikko A J Finnilä, Khaled Elkhouly, Amanda Sjögren, Aleksandra Turkiewicz, Patrik Önnerfjord, Velocity Hughes, Jon Tjörnstrand, Martin Englund, Simo Saarakkala

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

OBJECTIVE: To investigate the occurrence of meniscal calcifications in individuals with and without knee osteoarthritis (OA). Additionally, we aim to identify the specific types of calcifications: basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPP).

METHOD: We analysed 82 meniscal posterior horn samples (medial and lateral) collected from 41 human subjects. Among them, 20 individuals underwent total knee replacement due to medial compartment OA, while 21 deceased donors had no known knee OA. The assessment of meniscal calcifications and Pauli's histopathological scoring was conducted using histological sections. Furthermore, adjacent sections underwent measurement using Raman spectroscopy to characterize BCP and CPP calcifications based on their distinct spectral fingerprints.

RESULTS: All OA individuals exhibited calcifications in at least one meniscus, compared to 9.5% (95%CI 1%, 30%) of donors. Among 35 OA menisci with calcifications, 28(80%) had BCP, 5(14%) had CPP and 2(6%) had both types. In 4 donor menisci, 3(75%) had CPP while 1(25%) had both types. We estimated the association between Pauli score and presence of BCP in OA individuals, yielding an odds ratio of 2.1 (95%CI 0.8, 5.3) per 1 Pauli score. The association between Pauli score and presence of CPP (in whole study sample) seemed weaker, with odds ratio of 1.3 (95%CI 1.1, 1.7).

CONCLUSION: The presence of BCP was predominant in menisci of OA individuals, whereas CPP exhibited similar prevalence in individuals with and without OA. The formation of BCP crystals in menisci may represent an important and specific characteristic of OA disease process that warrants further attention.

Originalspråkengelska
Sidor (från-till)1443-1451
TidskriftOsteoarthritis and Cartilage
Volym32
Nummer11
Tidigt onlinedatum2024 aug. 6
DOI
StatusPublished - 2024

Bibliografisk information

Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Ämnesklassifikation (UKÄ)

  • Ortopedi

Fingeravtryck

Utforska forskningsämnen för ”Prevalence and classification of meniscal calcifications in the human knee”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här