Prevalence and functional impact of parkinsonian signs in older adults from the Good Aging in Skåne study: Parkinsonian signs in older adults

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Sammanfattning

Introduction
Mild parkinsonian signs (MPS) have been characterized by several definitions, using the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS). We aimed to investigate the prevalence of MPS and their association with functional level and comorbidities in the oldest old.

Method
Community-dwelling older adults (n = 559, median age 85, range 80–102 years) were examined regarding MPS, possible parkinsonism (PP) and subthreshold parkinsonism (SP) according to four previously used definitions and concerning the impact of parkinsonian signs on cognitive, physical, and autonomic function. MPS, PP and SP are different terms describing a very similar phenomenon and there is no gradation between these. In two of the four definitions more advanced symptoms were categorized as parkinsonism.

Results
Median UPDRS score in the whole study group was 10 points (range: 0–58) and was predominated by bradykinesia. MPS/PP/SP were present in 17–85%, and parkinsonism in 33–71% of the cohort. Independently of age and gender, MPS/PP/SP and especially parkinsonism, were associated with a higher risk of fear of falling and accomplished falls, with lower: cognition, ADL, physical activity and quality of life, and with urinary incontinence, obstipation and orthostatic intolerance.

Conclusions
In a population of older adults above 80 years, MPS are highly prevalent as well as more advanced symptoms defined as parkinsonism, and only 9–17% of the cohort is symptom-free. Predominance of bradykinesia in the oldest old might indicate a need for revision of MPS definitions to improve their sensibility.
Originalspråkengelska
Artikelnummer105416
Sidor (från-till)1-7
TidskriftParkinsonism and Related Disorders
Volym111
Tidigt onlinedatum2023 juni
DOI
StatusPublished - 2023

Ämnesklassifikation (UKÄ)

  • Geriatrik
  • Gerontologi, medicinsk/hälsovetenskaplig inriktning

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