Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

Min Kim, Ashfaq Ali, Cristina Legido-Quigley, et al.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

21 !!Citations (SciVal)

Sammanfattning

Introduction: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. Methods: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis. Results: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory. Discussion: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures. © 2019
Originalspråkengelska
Sidor (från-till)817-827
Antal sidor11
TidskriftAlzheimer's and Dementia
Volym15
Utgåva6
DOI
StatusPublished - 2019 jun
Externt publiceradJa

Ämnesklassifikation (UKÄ)

  • Neurovetenskaper

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