Probing Cage Relaxation in Concentrated Protein Solutions by X-Ray Photon Correlation Spectroscopy

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Sammanfattning

Diffusion of proteins on length scales of their size is crucial for understanding the machinery of living cells. X-ray photon correlation spectroscopy (XPCS) is currently the only way to access long-time collective diffusion on these length scales, but radiation damage so far limits the use in biological systems. We apply a new approach to use XPCS to measure cage relaxation in crowded α-crystallin solutions. This allows us to correct for radiation effects, obtain missing information on long time diffusion, and support the fundamental analogy between protein and colloid dynamical arrest.

Originalspråkengelska
Artikelnummer238001
Antal sidor6
TidskriftPhysical Review Letters
Volym129
Nummer23
DOI
StatusPublished - 2022 dec. 2

Ämnesklassifikation (UKÄ)

  • Fysikalisk kemi
  • Biofysik

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