Processed meat products with added plant antioxidants affect the microbiota and immune response in C57BL/6JRj mice with cyclically induced chronic inflammation

Stina Burri, Kajsa Granheimer, Marine Rémy, Vandana Tannira, Yunjeong So, Kimmo Rumpunen, Eva Tornberg, Pamela Canaviri Paz, Elisabeth Uhlig, Elin Oscarsson, Anne-Marie Rohrstock, Milladur Rahman, Åsa Håkansson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Epidemiological studies have found that there is a correlation between red and processed meat consumption and an increased risk of colorectal cancer. There are numerous existing hypotheses on what underlying mechanisms are causative to this correlation, but the results remain unclear. A common hypothesis is that lipid oxidation, which occurs in endogenous lipids and phospholipids in consumed food, are catalyzed by the heme iron in meat. In this study, five pre-selected plant antioxidant preparations (sea buckthorn leaves and sprouts, summer savory leaves, olive polyphenols, onion skin and lyophilized black currant leaves) were added to a meatball type prone to oxidize (pork meat, 20 % fat, 2% salt, deep-fried and after 2 weeks of storage). Pro-inflammatory markers, neutrophil infiltration and microbiota composition were studied after four months in a chronic inflammation model in C57BL6/J female mice. We found that the bacterial diversity index was affected, as well as initial immunological reactions.

Originalspråkengelska
Artikelnummer111133
TidskriftBiomedicine and Pharmacotherapy
Volym135
Tidigt onlinedatum2020 dec. 28
DOI
StatusPublished - 2021

Bibliografisk information

Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Ämnesklassifikation (UKÄ)

  • Immunologi inom det medicinska området

Fingeravtryck

Utforska forskningsämnen för ”Processed meat products with added plant antioxidants affect the microbiota and immune response in C57BL/6JRj mice with cyclically induced chronic inflammation”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här