Protease activity of Blastocystis hominis

Selena W S Sio, Manoj K Puthia, Alex S Y Lee, Jia Lu, Kevin S W Tan

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review


Parasite-derived proteases are important for the parasite life cycle and the pathogenesis of the disease they produce. Proteases of intestinal protozoan parasite Blastocystis hominis were studied for the first time with azocasein assays and gelatin SDS-PAGE analysis. Parasitic lysates were found to have high protease activity and nine protease bands of low (20-33 kDa) and high (44-75 kDa) molecular weights were reported. Proteases were found to be pH-dependent and highest proteolytic activity was observed at neutral pH. Inhibition studies showed that B. hominis isolate B, like many other protozoan parasites, contains mainly cysteine proteases.

Sidor (från-till)126-30
TidskriftParasitology Research
StatusPublished - 2006 juli
Externt publiceradJa

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi


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