TY - JOUR
T1 - Psychological manifestations of celiac disease autoimmunity in young children
AU - Smith, Laura B.
AU - Lynch, Kristian
AU - Kurppa, Kalle
AU - Koletzko, Sibylle
AU - Krischer, Jeffrey
AU - Liu, Edwin
AU - Johnson, Suzanne Bennett
AU - Agardh, Daniel
AU - Rewers, Marian
AU - Bautista, Kimberly
AU - Baxter, Judith
AU - Lernmark, Åke
AU - Aronsson, Carin Andrén
AU - Ask, Maria
AU - Bremer, Jenny
AU - Carlsson, Ulla Marie
AU - Cilio, Corrado
AU - Ericson-Hallström, Emelie
AU - Fransson, Lina
AU - Gard, Thomas
AU - Gerardsson, Joanna
AU - Bennet, Rasmus
AU - Hansen, Monica
AU - Hansson, Gertie
AU - Harmby, Cecilia
AU - Hyberg-Karlsson, Suzanne
AU - Johansen, Fredrik
AU - Jonsdottir, Berglind
AU - Larsson, Helena Elding
AU - Forss, Sigrid Lenrick
AU - Lundgren, Markus
AU - Månsson-Martinez, Maria
AU - Markan, Maria
AU - Melin, Marie Jessica
AU - Mestan, Zeliha
AU - Rahmati, Kobra
AU - Ramelius, Anita
AU - Rosenquist, Anna
AU - Salami, Falastin
AU - Sibthorpe, Sara
AU - Sjöberg, Birgitta
AU - Swartling, Ulrica
AU - Amboh, Evelyn Tekum
AU - Törn, Carina
AU - Wallin, Anne
AU - Wimar, Åsa
AU - Åberg, Sofie
AU - Lynch, Kristian
AU - Parikh, Hemang
AU - Vehik, Kendra
AU - TEDDY Study Group
PY - 2017/3/1
Y1 - 2017/3/1
N2 - BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were tested for tTGA beginning at 2 years of age. The Achenbach Child Behavior Checklist assessed child psychological functioning at 3.5 and 4.5 years of age. RESULTS: At 3.5 years, 66 mothers unaware their child had CDA reported more child anxiety and depression, aggressive behavior, and sleep problems than 3651 mothers of children without CDA (all Ps ≤ .03). Unaware-CDA mothers also reported more child anxiety and depression, withdrawn behavior, aggressive behavior, and sleep problems than 440 mothers aware of their child's CDA status (all Ps ≤.04). At 4.5 years, there were no differences. CONCLUSIONS: In 3.5-year-old children, CDA is associated with increased reports of child depression and anxiety, aggressive behavior, and sleep problems when mothers are unaware of their child's CDA status. Mothers' knowledge of their child's CDA status is associated with fewer reports of psychological symptoms, suggesting that awareness of the child's tTGA test results affects reporting of symptoms.
AB - BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were tested for tTGA beginning at 2 years of age. The Achenbach Child Behavior Checklist assessed child psychological functioning at 3.5 and 4.5 years of age. RESULTS: At 3.5 years, 66 mothers unaware their child had CDA reported more child anxiety and depression, aggressive behavior, and sleep problems than 3651 mothers of children without CDA (all Ps ≤ .03). Unaware-CDA mothers also reported more child anxiety and depression, withdrawn behavior, aggressive behavior, and sleep problems than 440 mothers aware of their child's CDA status (all Ps ≤.04). At 4.5 years, there were no differences. CONCLUSIONS: In 3.5-year-old children, CDA is associated with increased reports of child depression and anxiety, aggressive behavior, and sleep problems when mothers are unaware of their child's CDA status. Mothers' knowledge of their child's CDA status is associated with fewer reports of psychological symptoms, suggesting that awareness of the child's tTGA test results affects reporting of symptoms.
KW - celiac disease
KW - yong children
KW - psychological
UR - http://www.scopus.com/inward/record.url?scp=85016036285&partnerID=8YFLogxK
U2 - 10.1542/peds.2016-2848
DO - 10.1542/peds.2016-2848
M3 - Article
C2 - 28219962
AN - SCOPUS:85016036285
SN - 0031-4005
VL - 139
JO - Pediatrics
JF - Pediatrics
IS - 3
M1 - e20162848
ER -