Quantification of pulmonary pathology in cystic fibrosis-comparison between digital chest tomosynthesis and computed tomography

C. Meltzer, M. Gilljam, J. Vikgren, R. R. Norrlund, K. Vult Von Steyern, M. Båth, A. Johnsson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Extent of disease was quantified according to modality-specific scoring systems. Statistical analysis included Spearman's rank correlation coefficient (r) and Krippendorff's alpha (α). Major findings: The median effective dose was 0.14 for DTS and 2.68 for CT. Intermodality correlation was very strong for total score and the subscores regarding bronchiectasis and bronchial wall-thickening (r = 0.82-0.91, P < 0.01). Interobserver reliability was high for total score, bronchiectasis and mucus plugging (α = 0.83-0.93) in DTS. Conclusion: Chest tomosynthesis could be a low-dose alternative to CT in quantitative estimation of structural lung disease in CF.

Originalspråkengelska
Sidor (från-till)434-442
Antal sidor9
TidskriftRadiation Protection Dosimetry
Volym195
Utgåva3-4
DOI
StatusPublished - 2021 okt. 1
Externt publiceradJa

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Publisher Copyright:
© 2021 The Author(s) 2021 Published by Oxford University Press.

Ämnesklassifikation (UKÄ)

  • Radiologi och bildbehandling

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