TY - JOUR
T1 - Radiolabeled antibodies in prostate cancer: A case study showing the effect of host immunity on antibody bio-distribution.
AU - Vilhelmsson Timmermand, Oskar
AU - Santos, Elmer
AU - Thorek, Daniel L J
AU - Evans Axelsson, Susan
AU - Bjartell, Anders
AU - Lilja, Hans
AU - Larson, Steven M
AU - Strand, Sven-Erik
AU - Tran, Thuy
AU - Ulmert, David
PY - 2015
Y1 - 2015
N2 - Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissimilarity in bio-distribution of (111)In-DTPA-5A10, which targets free prostate specific antigen (fPSA), in two animal models.
AB - Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissimilarity in bio-distribution of (111)In-DTPA-5A10, which targets free prostate specific antigen (fPSA), in two animal models.
U2 - 10.1016/j.nucmedbio.2014.12.012
DO - 10.1016/j.nucmedbio.2014.12.012
M3 - Article
C2 - 25577038
SN - 1872-9614
VL - 42
SP - 375
EP - 380
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
IS - 4
ER -
