Reduced CSF CART in dementia with Lewy bodies.

Kristofer Schultz; Sara Wiehager; Karin Nilsson; Jørgen E Nielsen; Suzanne G Lindquist; Lena E Hjermind; Birgitte B Andersen; Anders Wallin; Christer Nilsson; Åsa Petersén

doi:10.1016/j.neulet.2009.02.008

Reduced CSF CART in dementia with Lewy bodies.

Kristofer Schultz, Sara Wiehager, Karin Nilsson, Jørgen E Nielsen, Suzanne G Lindquist, Lena E Hjermind, Birgitte B Andersen, Anders Wallin, Christer Nilsson, Åsa Petersén

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.

Originalspråk	engelska
Sidor (från-till)	104-106
Tidskrift	Neuroscience Letters
Volym	453
Nummer	2
DOI	https://doi.org/10.1016/j.neulet.2009.02.008
Status	Published - 2009

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Translational Neuroendocrinology (013210010)

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10.1016/j.neulet.2009.02.008

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http://www.ncbi.nlm.nih.gov/pubmed/19356602?dopt=Abstract

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title = "Reduced CSF CART in dementia with Lewy bodies.",

abstract = "Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.",

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T1 - Reduced CSF CART in dementia with Lewy bodies.

AU - Schultz, Kristofer

AU - Wiehager, Sara

AU - Nilsson, Karin

AU - Nielsen, Jørgen E

AU - Lindquist, Suzanne G

AU - Hjermind, Lena E

AU - Andersen, Birgitte B

AU - Wallin, Anders

AU - Nilsson, Christer

AU - Petersén, Åsa

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Translational Neuroendocrinology (013210010)

PY - 2009

Y1 - 2009

N2 - Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.

AB - Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.

U2 - 10.1016/j.neulet.2009.02.008

DO - 10.1016/j.neulet.2009.02.008

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SN - 0304-3940

VL - 453

SP - 104

EP - 106

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Reduced CSF CART in dementia with Lewy bodies.

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