Regional motion correction for in vivo photoacoustic imaging in humans using interleaved ultrasound images

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review


In translation from preclinical to clinical studies using photoacoustic imaging, motion artifacts represent a major issue. In this study the feasibility of an in-house algorithm, referred to as intensity phase tracking (IPT), for regional motion correction of in vivo human photoacoustic (PA) images was demonstrated. The algorithm converts intensity to phase-information and performs 2D phase-tracking on interleaved ultrasound images. The radial artery in eight healthy volunteers was imaged using an ultra-high frequency photoacoustic system. PA images were motion corrected and evaluated based on PA image similarities. Both controlled measurements using a computerized stepping motor and free-hand measurements were evaluated. The results of the controlled measurements show that the tracking corresponded to 97 ± 6% of the actual movement. Overall, the mean square error between PA images decreased by 52 ± 15% and by 43 ± 19% when correcting for controlled- and free-hand induced motions, respectively. The results show that the proposed algorithm could be used for motion correction in photoacoustic imaging in humans.
Sidor (från-till)3312-3322
Antal sidor11
TidskriftBiomedical Optics Express
StatusPublished - 2021 maj 12

Ämnesklassifikation (UKÄ)

  • Radiologi och bildbehandling
  • Oftalmologi


  • Image quality
  • In vivo imaging
  • Optical flow
  • Photoacoustic imaging
  • Spatial resolution
  • Spectral imaging

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