Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.

Anne-Sofie Grell; Rushani Thigarajah; Lars Edvinsson; Ajoy Kumar Samraj

doi:10.1371/journal.pone.0113624

Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.

Anne-Sofie Grell, Rushani Thigarajah, Lars Edvinsson, Ajoy Kumar Samraj

Medicin/akutsjukvård, Lund

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Sammanfattning

Increased expression of endothelin receptor type B (ETBR), a vasoactive receptor, has recently been implied in the reduced cerebral blood flow and exacerbated neuronal damage after ischemia-reperfusion (I/R). The study explores the regulatory mechanisms of ETBR to identify drug targets to restore normal cerebral artery contractile function as part of successful neuroprotective therapy.

Originalspråk	engelska
Artikelnummer	e113624
Tidskrift	PLoS ONE
Volym	9
Nummer	12
DOI	https://doi.org/10.1371/journal.pone.0113624
Status	Published - 2014

Ämnesklassifikation (UKÄ)

Annan klinisk medicin

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10.1371/journal.pone.0113624

Plos_Grell_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25479176?dopt=Abstract

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title = "Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.",

abstract = "Increased expression of endothelin receptor type B (ETBR), a vasoactive receptor, has recently been implied in the reduced cerebral blood flow and exacerbated neuronal damage after ischemia-reperfusion (I/R). The study explores the regulatory mechanisms of ETBR to identify drug targets to restore normal cerebral artery contractile function as part of successful neuroprotective therapy.",

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AU - Samraj, Ajoy Kumar

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AB - Increased expression of endothelin receptor type B (ETBR), a vasoactive receptor, has recently been implied in the reduced cerebral blood flow and exacerbated neuronal damage after ischemia-reperfusion (I/R). The study explores the regulatory mechanisms of ETBR to identify drug targets to restore normal cerebral artery contractile function as part of successful neuroprotective therapy.

U2 - 10.1371/journal.pone.0113624

DO - 10.1371/journal.pone.0113624

M3 - Article

C2 - 25479176

SN - 1932-6203

VL - 9

JO - PLoS ONE

JF - PLoS ONE

IS - 12

M1 - e113624

ER -

Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.

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Ämnesklassifikation (UKÄ)

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