Relationship between Atrial Oscillatory Acetylcholine Release Pattern and f-wave Frequency Modulation: A Computational and Experimental Study

Chiara Celotto, Carlos Sanchez, Konstantinos A. Mountris, Mostafa Abdollahpur, Frida Sandberg, Pablo Laguna, Esther Pucyo

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1 Citering (SciVal)
18 Nedladdningar (Pure)

Sammanfattning

The frequency of fibrillatory waves (f-waves), Ff, exhibits significant variation over time, and previous studies suggest that some of this variation is related to respiratory modulation through the autonomic nervous system. In this study, we tested the hypothesis that this variation (?Ff) could be related to acetylcholine concentration ([ACh]) release pattern. Electrocardiograms were recorded from seven patients during controlled respiration before and after full vagal blockade, from which f-wave frequency modulation was characterized. Computational simulations in human atrial tissues were performed to assess the effects of [ACh] release pattern on Ff and compared to experimental results in humans. A cross-stimulation protocol was applied onto the tissue to initiate a rotor while cyclically varying [ACh] following a sinusoidal waveform of frequency equal to 0.125 Hz. Different mean levels (0.05, 0.075µM/l) and peak-to-peak ranges (0.1, 0.05, 0.025 µM/l) of [ACh] variation were tested. In all patients, an f-wave frequency modulation could be observed. In 57% of the patients, this modulation was significantly reduced after vagal blockade. Simulations confirmed that rotor frequency variations followed the induced [ACh] patterns. Mean Ff was dependent on mean [ACh] level, while?Ffwas dependent on [ACh] variation range.

Originalspråkengelska
Titel på gästpublikation2020 Computing in Cardiology, CinC 2020
FörlagIEEE Computer Society
ISBN (elektroniskt)9781728173825
DOI
StatusPublished - 2020
Evenemang2020 Computing in Cardiology, CinC 2020 - Rimini, Italien
Varaktighet: 2020 sep 132020 sep 16

Publikationsserier

NamnComputing in Cardiology
Volym2020-September
ISSN (tryckt)2325-8861
ISSN (elektroniskt)2325-887X

Konferens

Konferens2020 Computing in Cardiology, CinC 2020
Land/TerritoriumItalien
OrtRimini
Period2020/09/132020/09/16

Ämnesklassifikation (UKÄ)

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